methyl 2-(3-(difluoromethoxy)phenyl)-2-methylpropanoate - Names and Identifiers
methyl 2-(3-(difluoromethoxy)phenyl)-2-methylpropanoate - Introduction
methyl 2-(3-(difluoromethoxy)phenyl)-2-methylpropanoate is an organic compound with the chemical formula C12H13F2O3.
Nature:
-Appearance: colorless liquid
-Melting point: approx. -13 ° C
-Boiling point: About 253 ° C
-Density: about 1.26g/cm³
-Refractive index: about 1.496
Use:
methyl 2-(3-(difluoromethoxy)phenyl)-2-methylpropanoate is commonly used as an intermediate for drugs and pesticides. It can be used to synthesize various organic compounds, such as antibiotics, pesticides, etc.
Method:
methyl 2-(3-(difluoromethoxy)phenyl)-2-methylpropanoate can be synthesized by the following steps:
1. Reaction of 3-(difluoromethoxy) benzaldehyde with methyl 2-methylpropionate under basic conditions yields 2-(3-(difluoromethoxy) phenyl)-2-methylmethacrylate.
2. The addition reaction of 2-(3-(difluoromethoxy) phenyl)-2-methyl methacrylate catalyzed by sulfuric acid produces 2-(3-(difluoromethoxy) phenyl)-2-Methylpropanol.
3. Reaction of 2-(3-(difluoromethoxy)phenyl)-2-methylpropanol with an excess of Formic Anhydride under acidic conditions gives methyl 2-(3-(difluoromethoxy)phenyl)-2-methylpropylanoate.
Safety Information:
methyl 2-(3-(difluoromethoxy)phenyl)-2-methylpropanoate is an organic compound, which should be used and handled safely. Its specific safety measures include but are not limited:
-Avoid contact with skin, eyes and respiratory tract. If contact occurs, rinse immediately with plenty of water.
-Wear appropriate personal protective equipment such as lab gloves, goggles and protective clothing during operation.
-Avoid contact with oxidants, strong acids, strong bases and other substances during storage.
-If swallowing or inhalation occurs, seek medical attention immediately and provide detailed information about the compound to the doctor.
Last Update：2024-04-09 02:00:52